A Neonatal Mouse Model of Coxsackievirus A16 for Vaccine Evaluation
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چکیده
منابع مشابه
Protection from lethal challenge in a neonatal mouse model by circulating recombinant form coxsackievirus A16 vaccine candidates
Circulating coxsackievirus A16 (CA16) is a major cause of hand, foot and mouth disease (HFMD) in South-east Asia. At present, there is no vaccine against CA16. Pathogenic animal models that are sensitive to diverse circulating CA16 viruses would be desirable for vaccine development and evaluation. In this study, we isolated and characterized several circulating CA16 viruses from recent HFMD pat...
متن کاملComparative pathogenicity of Coxsackievirus A16 circulating and noncirculating strains in vitro and in a neonatal mouse model
An enterovirus 71 (EV71) vaccine for the prevention of hand, foot, and mouth disease (HMFD) is available, but it is not known whether the EV71 vaccine cross-protects against Coxsackievirus (CV) infection. Furthermore, although an inactivated circulating CVA16 Changchun 024 (CC024) strain vaccine candidate is effective in newborn mice, the CC024 strain causes severe lesions in muscle and lung ti...
متن کاملCoxsackievirus A16 induced neurological disorders in young gerbils which could serve as a new animal model for vaccine evaluation
Coxsackievirus A16 (CA16) is one of the major pathogens associated with human hand, foot, and mouth disease (HFMD) in the Asia-pacific region. Although CA16 infections are generally mild, severe neurological manifestations or even death has been reported. Studies on CA16 pathogenesis and vaccine development are severely hampered because the small animal models that are currently available show ...
متن کاملRhombencephalitis and Coxsackievirus A16
References 1. Udo EE, Pearman JW, Grubb WB. Genetic analysis of community isolates of methicillin-resistant Staphylococcus au-reus in Western Australia. between Staphylococcus aureus strains carrying gene for Panton-Valentine leu-kocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Spread of a methicillin-resistant Staphylococcus aureus ST80-IV clone in a Danish co...
متن کاملCoxsackievirus type A16 infection in a neonate.
Hamilton, J. R., Lynch, M. J., and Reilly, B. J. (1969). Active coeliac disease in childhood. Quarterly Journal of Medicine, 38, 135-137. Lascari, A. D. (1973). Differential diagnosis. In Leukemia in Childhood, pp. 111-140. Edited by A. D. Lascari. Thomas: Springfield. Walker-Smith, J. (1975). Coeliac disease. In Diseases of the Small Intestine in Childhood, pp. 52-88. Edited by J. Walker-Smith...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2012
ISSN: 0022-538X
DOI: 10.1128/jvi.00902-12